Products name: Camptothecine 

Plant source: Whole herb of Camptotheca acuminata

Structural Formula

CAS number: 7689-03-4

Molecular formula: C20H16N2O4

Molecular weight: 348.34

Function

Camptothecin (CPT) is a cytotoxic quinoline alkaloid which inhibits the DNA enzyme topoisomerase I (topo I). It was discovered in 1966 by M. E. Wall and M. C. Wani in systematic screening of natural products for anticancer drugs. It was isolated from the bark and stem of Camptotheca acuminata (Camptotheca, Happy tree), a tree native to China used as a cancer treatment in Traditional Chinese Medicine.

CPT showed remarkable anticancer activity in preliminary clinical trials but also low solubility and (high) adverse drug reaction.

Characteristics: White powder

Specifications: 

Camptothecine 98% HPLC